The U.S.-South Korea civil nuclear relationship has evolved significantly over the decades–South Korea’s civil nuclear program first developed under U.S. technological guidance and patronage, and the two countries’ nuclear energy industries and establishments remain closely intertwined. What was once a relationship of tutelage has gradually transformed into a more equal partnership. Korea has established itself as a major global supplier of nuclear power technologies, and while U.S. firms continue to be involved in South Korean nuclear projects, the reverse is now also true. However, the future of this partnership is likely to have far-reaching effects beyond energy, industry, and commerce in the two countries. In the backdrop of intensifying competition in international nuclear markets, the expansion and continued progress of the U.S.-South Korea nuclear partnership may hold the key to addressing critical global issues: maintaining geopolitical relevance and influence in key regions; upholding robust international standards and practices in nuclear security and nonproliferation; and broadening access to safe, clean, and reliable energy in a world facing both rapid energy demand growth and increasing environmental pressures.